Now, as part of AbbVie, the program is well positioned to move into later stages of clinical development.". UCB - Inspired by patients. Follow @abbvie on Twitter, Facebook, Instagram, YouTubeand LinkedIn. Syndesi will build on a rich legacy of work by UCB to further develop these novel SV2A modulators to investigate their potential to improve cognition in diseases such as Alzheimers Disease, other dementias and cognitive impairment associated with schizophrenia. See the full leadership team at Craft. UCB is listed on Euronext Brussels (symbol: UCB). UCBs Neuroscience researchers in Belgium have designed a unique class of novel SV2A modulators. document.getElementById('cloak45869').innerHTML = ''; North Chicago, Illinois-based AbbVie announced Tuesday that it paid $130 million up front to acquire Syndesi Therapeutics. All rights reservedLast updated on:April, 07, 2022, Syndesi Therapeutics is based in Belgium and will leverage UCBs neurology expertise in modulating the synaptic vesicle protein SV2A. The UK Life Sciences team advised Syndesi Therapeutics and its shareholders on Syndesi's acquisition by AbbVie (NYSE: ABBV). The lead molecule, SDI-118, is a small molecule currently in Phase 1b studies, which is being evaluated to target nerve terminals to enhance synaptic efficiency. MT . Syndesi's unique molecules act pre-synaptically to enhance synaptic efficiency by positively modulating the function of synaptic vesicle protein 2A (SV2A), which plays a central role in regulating neurotransmission. About Syndesi Therapeutics . All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including estimates of revenues, operating margins, capital expenditures, cash, other financial information, expected legal, political, regulatory or clinical results and other such estimates and results. Important factors that could result in such differences include: changes in general economic, business and competitive conditions, the inability to obtain necessary regulatory approvals or to obtain them on acceptable terms, costs associated with research and development, changes in the prospects for products in the pipeline or under development by UCB, effects of future judicial decisions or governmental investigations, product liability claims, challenges to patent protection for products or product candidates, changes in laws or regulations, exchange rate fluctuations, changes or uncertainties in tax laws or the administration of such laws and hiring and retention of its employees. according to fleur jeffries of pm live, "the acquisition further reinforces abbvie's neurology pipeline, as four years ago, syndesi therapeutics gained the rights to ucb's synaptic vesicle protein 2a (sv2a) programme, which aims to achieve synaptic efficiency, targeting the communication between neurons in the brain, which - most notably in Fountains main office is in Dublin, Ireland, with a second office in New York. Syndesi Therapeutics was established to develop a series of novel, pro-cognitive small molecule SV2A modulators licensed from UCB. With an upfront payment of $130 million, AbbVie gains Syndesi's portfolio of novel modulators of the synaptic vesicle protein 2A (SV2A), including its lead molecule SDI-118. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. "Le dynamisme de notre activit, combin aux avances de notre pipeline, continue de soutenir les perspectives prometteuses d'AbbVie long terme." Sur une base GAAP, le ratio de marge brute du deuxime trimestre tait de 71,4 %. Therapeutic botox accounted for $2.45 billion in 2021 sales, making it the companys top neuro product. We are deploying our platform to build a pipeline of first-in-class small molecules to address high priority cancer targets that have evaded conventional discovery approaches. Syndesi Therapeutics has raised a total of 26.2M in funding over 3 rounds. The company's drugs can modulate the synaptic vesicle protein to handle the transmission between neurons in the brain to effectively treat Alzheimer's and other disorders with cognitive impairment, enabling healthcare providers to treat these diseases with the right therapy at their disposal. Alkermes Weighs Splitting Off Cancer Biz as Separate, Publicly Traded Company, The 2 Things That Made My Transition to Voice Tech Easier: A Friendly Pricing Model and Easy Implementation, Patient Files Class-action Suit Against Advocate Aurora Health Following Data Breach, Why are Healthcare Costs So High? Moreover, sales may be impacted by international and domestic trends toward managed care and health care cost containment and the reimbursement policies imposed by third-party payers as well as legislation affecting biopharmaceutical pricing and reimbursement. Anthos Therapeutics is a clinical-stage biopharmaceutical company focused on the development and commercialization of genetically and pharmacologically validated innovative therapies to advance care for people living with cardiovascular and metabolic (CVM) diseases. Obsidian Therapeutics is using its proprietary cytoDRiVE platform to harness the power of proteins to engineer precision medicines. "I am delighted with the closing of this deal. Four years after spinning out from Belgium's UCB, Syndesi Therapeutics and its SV2A modulator programme has been bought by AbbVie for $130 million upfront. The company is the holding company in the Novo Group, comprising Novo Nordisk A/S, Novozymes A/S and NNIT A/S, and is responsible for managing the Foundations assets. The mechanism is currently being evaluated for the potential treatment of cognitive impairment and other symptoms associated with a range of neuropsychiatric and neurodegenerative disorders, such as Alzheimer's disease and major depressive disorder. Therefore we make use of cookies. SIRP-DIRECTED ANTIBODIES IN DEVELOPMENT Our novel monoclonal antibodies are designed to change the lives of patients with immunological diseases and cancer. . SRIW Socit Rgionale d'Investissement de Wallonie (www.sriw.be) provides equity and/or debt to companies that generate added value and employment in Wallonia. Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic . In addition to being the major shareholder in the Novo Group companies, Novo Holdings provides seed and venture capital to development-stage companies, takes significant ownership positions in well-established companies within the life sciences and manages a broad portfolio of financial assets. Syndesi Therapeutics' lead pipeline candidate is SDI-118. Follow us on Twitter: @UCB_news. Get the latest industry news first when you subscribe to our newsletter. Four years after spinning out from Belgium's UCB, Syndesi Therapeutics and its SV2A modulator programme has been bought. Syndesi, which is based in Belgium, aims to treat brain disorders by reducing the symptoms of cognitive impairment. Milestone payments could bring shareholders of the biotech up to $870. OUR PIPELINE JOIN US TODAY In June last year, AbbVie exercised an exclusive option for the acquisition of TeneoOne, a Teneobiosubsidiary. V-Bio Ventures (www.v-bio.ventures) is an independent venture capital firm specialized in building and financing young, innovative life science companies. COPENHAGEN, Denmark, March 1, 2022 /PRNewswire/ -- Novo Holdings, a leading international life sciences investor, today announces that its portfolio company Syndesi Therapeutics ('Syndesi'). Syndesi Therapeutics SA, a clinical stage biotechnology company developing novel modulators of the synaptic vesicle protein SV2A for the treatment of cognitive impairment, announces results from two Phase I studies of its lead compound SDI-118, supporting further development of this promising molecule. Regulating synaptic transmission represents a promising approach to treating Alzheimer's Disease and other disorders with cognitive impairment. More from news Approximately 1 fully matching, plus 0 partially . 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Products or potential products which are the subject of partnerships, joint ventures or licensing collaborations may be subject to differences between the partners. read more 14 Dec By identifying and optimizing allosteric binding sites that have never before been targeted, Gain is unlocking new treatment options for difficult-to-treat disorders characterized by protein misfolding, including lysosomal storage disorders. Johnson & Johnson Innovation JJDC Inc. (JJDC) is the strategic venture capital arm of Johnson & Johnson and a long-term investment partner to global healthcare entrepreneurs. Synaptic dysfunction, with the consequent disruption of connectivity bet ween brain regions, underlies cognitive impairment seen in multiple CNS . All rights reserved. Syndesi Therapeutics is developing molecules that modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). This acquisition gives AbbVie access to Syndesi's portfolio of novel modulators of the synaptic vesicle protein 2A (SV2A), including its lead molecule SDI-118. Innovative Med Concepts USA Private Innovative Med Concepts is a biotech company with a pipeline of novel treatments for fibromyalgia and other related . Revolutionary intracellular screening platform creates new opportunities to discover first-in-class therapeutics to address challenging disease targets. The pharmaceutical giant is taking steps to remedy that deficiency by striking a deal: the acquisition of a UCB spinout thats already reached the clinic with a drug that takes a new approach to brain disorders and has potential applications that include Alzheimers disease. About Syndesi Therapeutics Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. It has been a pleasure to partner with our investors to investigate the potential of SDI-118 in early clinical studies. With AbbVies acquisition of Syndesi, we aim to advance the research of a novel, first-in-class asset for the potential treatment of cognitive impairment associated with neuropsychiatric and neurodegenerative disorders.. The AbbVie/Calico alliance, started in 2014, has advanced three programs to clinical testing in neurodegeneration and cancer. As hospitals face consolidation and CIOs are asked to increase staff productivity, tech companies that can support automation with solutions that are easy to onboard are getting heightened interest. THE INNOVATIVE TEAM AT ELECTRA THERAPEUTICS Our team expands the possibilities of science to create transformative therapies for patients in need. Syndesi Therapeutics is developing molecules which act in a unique way on the synaptic vesicle protein SV2A. SRIW facilitates the region's economic development, contributing effectively to the modernisation, growth and restructuring of the businesses that make up the Walloon industrial network. The lead molecule, SDI-118, is a small molecule currently in Phase 1b studies, which is being evaluated to target nerve terminals to enhance synaptic efficiency. Syndesi Therapeutics is developing molecules that uniquely modulate the synaptic vesicle protein SV2A, which plays a central role in synaptic transmission (the communication between neurons in the brain). Synaptic dysfunction is believed to underlie the cognitive impairment seen in multiple neuropsychiatric and neurodegenerative disorders. Syndesi has an exclusive, worldwide license from UCB to develop and commercialise a series of novel, pro-cognitive SV2A modulators. V-Bio Ventures was established in 2015 and works closely with Belgium-based VIB, one of the worlds premier life science institutes. Its current portfolio fair value is above 150 million . North Chicago, Illinois-based AbbVie announced Tuesday that it paid $130 million up front to acquire Syndesi Therapeutics. Lead Syndesi drug candidate SDI-118 came from UCB research of molecules that regulate SV2A, but to improve cognition rather than stop epileptic seizures. Syndesis molecule is currently in early-stage clinical development as a way to target nerve terminals to enhance synaptic efficiency. I am thrilled to be working with the company which is supported by scientists at UCB and able to leverage Janssen neuroscience expertise via a presence at the JLINX incubator, all in an effort to develop products that could one day make a meaningful difference for patients suffering from cognitive impairment.. and we will provide you with regular updates. Cleary Gottlieb Steen & Hamilton LLP acted as legal counsel to AbbVie. We make long term investments in early stage companies in the US and Europe. 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AbbVie will pay Syndesi's shareholders a $130 million upfront payment with the potential for Syndesi's shareholders to receive additional contingent payments of up to $870 million based on the achievement of certain predetermined milestones. document.getElementById('cloak45869').innerHTML += '' + addy45869+'<\/a>'; Fountain Healthcare Partners (www.fh-partners.com) is a life science focused venture capital fund with 176 million ($200 million) under management. Regulating synaptic transmission represents a promising approach to treating Alzheimer's Disease and other disorders with cognitive impairment. Sirona's current pipeline includes further cosmetic related products for cell preservation and repair, keloid therapy, scar therapy, anti-aging, anti-wrinkle, and . var path = 'hr' + 'ef' + '='; Join our mailing list. IMPROVING THE LIVES OF PATIENTS AND THEIR FAMILIES. 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Request Profile Update Download Data Home Profiles Pharmaceutical Company Europe Syndesi Therapeutics Syndesi Therapeutics Details Syndesi Therapeutics Contact Information Get News Stories Delivered to Your Inbox Your Email: Join Today AbbVie Acquires Syndesi Therapeutics, Strengthening Neuroscience Portfolio. On Mar 2, 2022 AbbVie announced it has completed the acquisition of Syndesi Therapeutics SA, which will help to expand AbbVie's neuroscience portfolio. Our Pipeline Job Postings. Also, UCB or others could discover safety, side effects or manufacturing problems with its products after they are marketed. There is a major unmet need for new therapies that can help improve cognitive function in patients suffering from difficult-to-treat neurologic diseases, Hudson said in a prepared statement. The funds (VIVES I - 15 million and VIVES II - 43 million) are managed by SOPARTEC, UCLs technology transfer company, member of the Louvain Technology Transfer Office. Syndesi Therapeutics is funded by 9 investors. //-->. By their nature, such forward-looking statements are not guarantees of future performance and are subject to risks, uncertainties and assumptions which could cause actual results to differ materially from those that may be implied by such forward-looking statements contained in this press release. The mechanism is now being studied to potentially treat cognitive impairment and other symptoms linked to various neurodegenerative and neuropsychiatric diseases such as major depressive disorder and Alzheimers disease. Bone Therapeutics has a broad portfolio of innovative allogeneic cell therapy solutions across a range of indications. - Expands AbbVie's neuroscience portfolio, adding first-in-class modulators of the synaptic vesicle protein 2A, including lead molecule SDI-118 currently in Phase 1b studies, - Novel mechanism will be evaluated for the potential to mitigate synaptic dysfunction associated with cognitive deficits across a range of neuropsychiatric and neurodegenerative disorders. Share. Presently in Phase Ib clinical trials, SDI-118 is being analysed for its potential ability to boost synaptic efficiency by acting on nerve terminals. Registration or use of this site constitutes acceptance of our Terms of Service and Privacy Policy. Novo Holdings and Fountain Healthcare Partners are the most recent investors. The product, which came to AbbVie in the 2020 Allergan acquisition, is approved for a range of therapeutic indications that include treating muscle spasticity from a stroke or other injury, as well as preventing migraine headaches. Founded in 1973, JJDC continues a legacy of customizing deals for data-driven companies across the continuum of healthcare, with the goal of turning great ideas into transformative new pharmaceutical, medical device and consumer healthcare products. AbbVie announced it has completed the acquisition of Syndesi Therapeutics SA, which will help to expand AbbVie's neuroscience portfolio. More. The company has also benefited from support from the Walloon Region. About Syndesi Therapeutics Founded in December 2017 and based in Belgium, Syndesi is a clinical stage biotechnology company pioneering the development of novel therapeutics that modulate synaptic function to relieve the symptoms of cognitive impairment. . Cognitive impairment observed in various neuropsychiatric and neurodegenerative ailments is claimed to be triggered by synaptic dysfunction. We are excited to see Syndesi develop our novel pro-cognitive SV2A modulators to create value for patients with cognitive impairment, said Dhavalkumar Patel, UCBs Chief Scientific Officer and Executive Vice President. Unlike, UCB is the world leader in SV2A research, having discovered and developed two major anti-epileptic drugs treating patients around the world. The mechanism is currently being evaluated . This investment group formed Syndesi in 2017; the startup licensed SDI-118 from UCB in 2018. PIPELINE. Syndesi, which takes its name from the Greek word for connection, develops drugs that target synaptic vesicle protein 2A (SV2A), a protein that plays a key role in regulating neurotransmission. They are also entitled to get further contingent payments of up to $870m on meeting specific pre-set milestones. Syndesi Therapeutics (www.syndesitherapeutics.com) has been established at the Centre dEntreprises et dInnovation (CEI) in Louvain-la-Neuve and will have a presence at the JLINX incubator facilities to access expertise at the Janssen campus in Beerse, Belgium.
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